These articles are among the most important that have been published in the field since it’s inception in 1999. It is useful to remember that the technology of TNE has now been available for more than a decade. Under each article is a brief synopsis that highlight its key point(s) and importance. Those shown here are all seminal, landmark papers.

Amin MR, Postma GN, Setzen M, Koufman JA. Transnasal esophagoscopy: A position statement from the American Broncho-Esophagological Association. Otolaryngol Head Neck Surg 138:411-3, 2008.

This overview paper includes a literature review.  The paper concludes that TNE is the safest and most cost-effective method of esophageal screening for Barrett’s and esophageal cancer.  Click here for a printable PDF of this article

Belafsky PC, Postma GN, Daniel E, Koufman JA. Transnasal esophagoscopy. Otolaryngol Head Neck Surg 15:588-9, 2001.

This was the first series published from Dr. Koufman’s group at Wake Forest University; 200 cases were reported as well as some novel applications for TNE.  Click here for a printable PDF of this article

Koufman JA, Belafsky PC, Daniel E, et al. Prevalence of esophagitis in patients with pH-documented laryngopharyngeal reflux.  Laryngoscope 112:1606-9, 2002.

This landmark, prospective, clinical study helped define the ways in which laryngopharyngeal reflux (LPR) is different than classic gastroesophageal reflux disease (GERD). Fifty-eight unselected and consecutive patients with both clinical and pH-documented LPR underwent TNE with biopsy.  Only 12% had esophagitis and another 7% had Barrett’s esophagus (a precursor to esophageal cancer. Click here for a printable PDF of this article

Reavis KM, Morris CD, Gopal DV, Hunter JG, Jobe BA. Laryngopharyngeal reflux symptoms better predict the presence of esophageal adenocarcinoma than typical gastroesophageal reflux symptoms. Ann Surg 239:849-56, 2004.

This is a ‘game changing’ paper. That Barrett’s esophagus (esophageal precancer) is found in patients with LPR (e.g., hoarseness, chronic cough) more often than in typical GERD patients with GI symptoms (e.g., heartburn), means that screening endoscopy (TNE) should be performed in LPR as well as GERD patients.  Click here for a printable PDF of this article

Postma GN, Cohen JT, Belafsky PC, Halum SL, Gupta SK, Bach KK, Koufman JA. Transnasal esophagoscopy revisited (over 700 consecutive cases). Laryngoscope 115:321-3, 2005.

World’s largest series (N= 700) to date, also reporting the findings in LPR patients. Click here for a printable PDF of this article

Aviv JE. Transnasal Esophagoscopy: State of the Art. Otolaryngol Head Neck Surg 135:616-19, 2006.

Excellent review article by one of the pioneers in the field of TNE. Click here for a printable PDF of this article

Koufman JA, Stern JC, Bauer MM. Dropping Acid: The Reflux Diet Cookbook & Cure. Reflux Cookbooks LLC (Brio Books), Minneapolis MN, 2010.

In the “Science You Can Digest” chapter of this book, Dr. Koufman explains the history of reflux and why it is now epidemic; see  www.refluxcookbook.com and especially the blog. The book may be purchased on Barnes and Noble’s website or Amazon.  Finally, there is a book trailer on YouTube.

Aviv JE, Takoudes TG, Ma G, Close LG. Office-Based Esophagoscopy: A preliminary Report. Otolaryngol Head Neck Surg 125:170-5, 2001.

This is the first publication on transnasal esophagoscopy (TNE); Dr. Aviv et al. reported 20 cases. Click here for a printable PDF of this article (This link is under construction)

Postma GN, Bach KK, Belafsky PC, Koufman JA. The role of transnasal esophagoscopy in head and neck oncology. Laryngoscope 112:2242-3, 2002.